Long-term prospective assessment of subconjunctival triamcinolone acetonide in addition to topical therapy in the management of chronic superficial keratitis

Simple item page
dc.contributor.authorBETEG, Florin
dc.contributor.authorLELESCU, Cristina
dc.contributor.authorURDĂ-CÎMPEAN, Andrada
dc.contributor.authorTAULESCU, Marian
dc.contributor.authorMURESAN, Cosmin
dc.contributor.departmentVeteriner Fakültesitr_TR
dc.date.accessioned2021-10-11T12:06:30Z
dc.date.available2021-10-11T12:06:30Z
dc.date.issued2020-12-25
dc.description.abstractChronic superficial keratitis (CSK) is a progressive inflammatory disease in adult dogs, associated with corneal vascular proliferation, edema and melanic pigment deposition. In the absence of a curative therapy, the current approach for the management of CSK aims to control disease progression and eventually decrease the severity of corneal lesions. Subconjunctival injections of corticosteroids may be effective in severe cases, where topical therapy alone is inadequate. The aim of this study was to comprehensively evaluate the effectiveness of subconjunctival triamcinolone acetonide (TA) injection in addition to topical steroid treatment for the long-term management of CSK, in dogs unresponsive to conventional topical steroids. Treatment efficacy was assessed in 11 dogs with bilateral CSK by periodic evaluation of the cornea in terms of vascularization, edema and pigmentation for up to 120 weeks. Clinically significant reductions in corneal pigmentation (P<0.0001), vascularization (P<0.0001) and edema scores (P<0.0001) were achieved during therapy. The greatest reduction was exhibited by corneal edema, closely followed by vascularization. Corneal pigmentation was less responsive and complete regression has not been achieved in any of the dogs. Severely affected corneas exhibited greater improvements in terms of pigmentation, whereas moderately affected corneas showed a slight decrease. Corneal edema and vascularization were adequately controlled, whereas corneal pigmentation exhibited a lower decrease in severity and was more difficult to manage on a long-term basis. This study suggests that subconjunctival injection of TA in addition to topical steroids could represent an effective option for long-term management of CSK in dogs unresponsive to topical steroids alonetr_TR
dc.identifier.endpage68tr_TR
dc.identifier.issn/e-issn1308-2817
dc.identifier.issue1tr_TR
dc.identifier.startpage61tr_TR
dc.identifier.urihttps://doi.org/10.33988/auvfd.724846tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/75370
dc.identifier.volume68tr_TR
dc.language.isoentr_TR
dc.publisherAnkara Üniversitesitr_TR
dc.relation.isversionof10.33988/auvfd.724846tr_TR
dc.relation.journalAnkara Üniversitesi Veteriner Fakültesi Dergisitr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.subjectChronic superficial keratitistr_TR
dc.subjectDogstr_TR
dc.subjectSubconjunctivaltr_TR
dc.titleLong-term prospective assessment of subconjunctival triamcinolone acetonide in addition to topical therapy in the management of chronic superficial keratitistr_TR
dc.typeArticletr_TR

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
8.pdf
Size:
637.45 KB
Format:
Adobe Portable Document Format
Description:
Dergi
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.62 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Cilt:68 Sayı:01 (2021)