Wound healing effect of Anzer origin propolis specimens on rats’ intestinal incision

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dc.contributor.authorSarıtaş, Zülfikar
dc.contributor.departmentOthertr_TR
dc.contributor.facultyOthertr_TR
dc.date.accessioned2022-11-10T12:43:41Z
dc.date.available2022-11-10T12:43:41Z
dc.date.issued2022
dc.description.abstractThis study was investigated the wound healing effect of Anzer origin propolis specimens on rats’ experimental intestinal incisions. Thirty-four male Wistar albino rats have been divided into five groups, weighing 250-300 gr. Water solution of Anzer propolis (PW3 [n=6], PW7 [n=6]) or ethanolic solution of Anzer propolis (PE3 [n=6], PE7 [n=6]) were administered. Control groups (K3 [n=5], K7 [n=5]) received no treatment. The surgical procedure (day 0) consisted of a laparotomy under general anesthesia, during which the colon was incised and repaired with sutures. The Anzer propolis specimen diluted with physiologic saline was administered by gavage (100 mg/kg/day) for 3 and 7 days before and after surgery to PW3 and PW7 groups. Ethanol dissolved Anzer propolis was administered by gavage (100 mg/kg/day) for 3 and 7 days before and after surgery to PE3 and PE7. Experimental animals have been humanly euthanized on the 3rd and 7th days for biochemical and histopathological evaluations. Serum total oxidant status, total antioxidant status, interleukin-1, interleukin-6, tumor necrosis factor-alpha, myeloperoxidase, hydroxyproline and nitric oxide, levels were measured by ELISA. The incision line sampled to evaluate inflammatory cells, fibroblastic activity, neovascularization, and collagen level. The study indicates that the ethanolic Anzer propolis solution's oral administration has a beneficial effect on intestinal wound healing for seven days pre-and postoperatively (PE7).tr_TR
dc.description.indexTrdizintr_TR
dc.identifier.urihttps://doi.org/10.33988/auvfd.834703tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/85380
dc.language.isotrtr_TR
dc.publisherAnkara Üniversitesi Veteriner Fakültesitr_TR
dc.relation.isversionof10.33988/auvfd.834703tr_TR
dc.relation.journalAnkara Üniversitesi Veteriner Fakültesi Dergisitr_TR
dc.relation.publicationcategoryGazete Makalesi - Ulusaltr_TR
dc.subjectAnzer Propolistr_TR
dc.subjecttotal oxidant statustr_TR
dc.subjectotal oxidant statustr_TR
dc.titleWound healing effect of Anzer origin propolis specimens on rats’ intestinal incisiontr_TR
dc.typeArticletr_TR

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Cilt:69 Sayı:01 (2022)