The research of 1,2,4-triazole derivatives hepatoprotective activity under tetracycline and infectious hepatitis
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Date
2019
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Publisher
Ankara : Ankara Üniversitesi
Abstract
Objective: The purpose of this work is to study the hepatoprotective properties of potassium 2-((4-amino5-(morpholinomethyl)-4H-1,2,4-triazole-3-yl)thio)acetate on tetracycline and infectious hepatitis models in
chickens.
Material and Method: Biochemical examination of blood and liver serum was carried out on intact
broiler chickens Cross Cobb 500. All groups of chickens were kept separately in different cages in the same
room with the same microclimate parameters in accordance with the established requirements.
Result and Discussion: Hepatoprotective effect of potassium 2-((4-amino-5-(morpholinomethyl)-4H1,2,4-triazole-3-yl)thio)acetate was established as a result of research on the model of hepatitis in chickens
caused by tetracycline, which was not lower than the referent drug - Thiotriazolin®. The biochemical study
results demonstrated hepatoprotective properties of the combination of the above compound with the antibiotic
Saroflox®, combination of potassium 2-((4-amino-5- (morpholinomethyl)-4H-1,2,4-triazole-3-yl) thio) acetate
with classical antibiotic Enrofloxacin® on the model of infectious hepatitis.
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Keywords
Biochemical indicators, Hepatoprotective activit