Microwave synthesis of new 3-(alkylthio)-5-(thiophen2-ylmethyl)-1,2,4-triazol-4-amines
| dc.contributor.author | Safonov, Andrii A. | |
| dc.contributor.authorID | https://orcid.org/0000-0003-2861-1826 | tr_TR |
| dc.contributor.department | Eczacılık Fakültesi | tr_TR |
| dc.date.accessioned | 2020-04-25T11:06:45Z | |
| dc.date.available | 2020-04-25T11:06:45Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Objective: The aim of this work is to synthesize 3-(alkylthio)-5-(thiophen-2-ylmethyl)-1,2,4-triazol-4- amines by the Milestone Flexi Wave microwave synthesis system and to prove structure synthesized compounds. Material and Method: The initial compounds 3-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-5-thioles (1-5) were synthesized at the Department of Toxicological and Inorganic Chemistry of the Zaporizhzhya State Medical University (Ukraine). Milestone Flexi Wave microwave synthesis system was used to synthesize 3- (alkylthio)-5-(thiophen-2-ylmethyl)-1,2,4-triazol-4-amines. The elemental analysis of synthesized compounds was established by the universal analyzer Elementar Vario L cube (CHNS). The 1 H spectra (at 400 MHz and 100 MHz) were recorded in DMSO-d6 on a Varian MR-400 spectrometer and analysed with ADVASP™ Analyzer program. The completeness of the reactions and the individuality of the resulting compounds were controlled by the gas chromatograph Agilent 7890B with a 5977B mass spectrometry detector. Result and Discussion: The reaction was carried out in an alcoholic medium by adding a catalytic amount of HCl to 5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiols. Methyl and i-propyl alcohols were used as alcohols. The mixture was heated for 45 minutes at a temperature of 150°C, a pressure 14.4 bar, ΔMW = 200 W. The signals of 1 H NMR for (4a-b, 6a-j) are consented with the proposed structure. The elemental analysis (CHNS) was accomplished for synthesized compounds to confirm their basic chemical structures and revealed acceptable agreement with the calculated percentages. | tr_TR |
| dc.identifier.endpage | 98 | tr_TR |
| dc.identifier.issn/e-issn | 1015-3918 | |
| dc.identifier.issue | 01 | tr_TR |
| dc.identifier.startpage | 89 | tr_TR |
| dc.identifier.uri | https://doi.org/10.33483/jfpau.620599 | tr_TR |
| dc.identifier.uri | http://hdl.handle.net/20.500.12575/71151 | |
| dc.identifier.volume | 44 | tr_TR |
| dc.language.iso | en | tr_TR |
| dc.publisher | Ankara Üniversitesi | tr_TR |
| dc.relation.isversionof | 10.33483/jfpau.620599 | tr_TR |
| dc.relation.journal | Ankara Üniversitesi Eczacılık Fakültesi Dergisi | tr_TR |
| dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi - Başka Kurum Yazarı | tr_TR |
| dc.subject | 1,2,4-triazole, synthesis | tr_TR |
| dc.subject | Heterocyclic compounds | tr_TR |
| dc.title | Microwave synthesis of new 3-(alkylthio)-5-(thiophen2-ylmethyl)-1,2,4-triazol-4-amines | tr_TR |
| dc.title.alternative | Yeni 3-(alkiltiyo)-5-(tiyofen-2-ilmetil)-1,2,4-triazol-4-aminlerin mikrodalga sentezi | tr_TR |
| dc.type | Article | tr_TR |