Formulation and detailed characterization of voriconazole loaded in situ gels for ocular application

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dc.contributor.authorOkur, Neslihan Üstündağ
dc.contributor.authorYozgatlı, Vildan
dc.contributor.authorŞenyiğit, Zeynep
dc.contributor.authorIDhttps://orcid.org/0000-0002-3210-3747tr_TR
dc.contributor.authorIDhttps://orcid.org/0000-0001-8018-6500tr_TR
dc.contributor.authorIDhttps://orcid.org/0000-0002-4920-2469tr_TR
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.date.accessioned2020-04-25T10:44:06Z
dc.date.available2020-04-25T10:44:06Z
dc.date.issued2020
dc.description.abstractObjective: This study was aimed to prepare, characterize and evaluate in situ gel formulation for a sustained ocular delivery of voriconazole. Material and Method: In situ gels were prepared with three different hydrophilic co-polymers: Poloxamer 188, 407 and 388. The formulations were characterized in terms of their clarity, pH, viscosity drug content uniformity and mechanical/rheological properties. Moreover, in vitro drug release and stabilitystudies were performed. Result and Discussion: The results showed that the optimized in situ gel formulation had desired in vitro properties and a good stability over the period of 3 months. Texture profile analysis presented that formulations offered suitable adhesive and mechanical properties. P2-V formulation exhibited pseudoplastic flow and typical gel-type mechanical spectra (G′ > G″) at different frequecy values and at different temperatures. Moreover, all formulations showed a sustained drug release for 24 hours. In conclusion, voriconazole loaded in situ gel could be offered as an encouraging strategy as ocular systems for ocular infections treatment.tr_TR
dc.identifier.endpage49tr_TR
dc.identifier.issn/e-issn1015-3918
dc.identifier.issue01tr_TR
dc.identifier.startpage33tr_TR
dc.identifier.urihttps://doi.org/10.33483/jfpau.586590tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/71147
dc.identifier.volume44tr_TR
dc.language.isoentr_TR
dc.publisherAnkara Üniversitesitr_TR
dc.relation.isversionof10.33483/jfpau.586590tr_TR
dc.relation.journalAnkara Üniversitesi Eczacılık Fakültesi Dergisitr_TR
dc.relation.publicationcategoryMakale - Ulusal - Editör Denetimli Dergi - Başka Kurum Yazarıtr_TR
dc.subjectMechanical properties poloxamertr_TR
dc.subjectRheological propertiestr_TR
dc.subjectVoriconazoletr_TR
dc.subjectMekanik özellikler poloksamertr_TR
dc.subjectReolojik özelliklertr_TR
dc.subjectVorikonazoltr_TR
dc.titleFormulation and detailed characterization of voriconazole loaded in situ gels for ocular applicationtr_TR
dc.title.alternativeOküler uygulama için vorikonazol yüklü in situ jellerin formülasyonu ve detaylı karakterizasyonutr_TR
dc.typeArticletr_TR

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Cilt:44 Sayı:01 (2020)