Design, synthesis, antimicrobial and antifungal activities of new 1,2,4-triazole derivatives containing 1h-tetrazole moiety

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dc.contributor.authorFrolova, Yuliia
dc.contributor.authorKaplaushenko, Andriy
dc.contributor.authorNagornaya, Nataliya
dc.contributor.authorIDhttps://orcid.org/0000-0002-3995-5088tr_TR
dc.contributor.authorIDhttps://orcid.org/0000-0003-3704-5539tr_TR
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.date.accessioned2020-04-25T11:03:38Z
dc.date.available2020-04-25T11:03:38Z
dc.date.issued2020
dc.description.abstractObjective: Antimicrobials and antifungals are the most acquired drugs in the world. Today, it becomes necessary to create new drugs with antimicrobial and antifungal effect. The purpose of our research is the synthesis of new series of 5-(1Н-tetrazole-1-yl)-4H-1,2,4-triazole-3-amine, the establishment of physicalchemical, antimicrobial and antifungal properties for all synthesized compounds. Material and Method: 5-(1Н-tetrazole-1-yl-methyl)-4H-1,2,4-triazole-3-yl-1-(alkyl-, aryl-)-methanimines were synthesized by reacting of 5-(1H-tetrazole-1-yl-methyl)-4H-1,2,4-triazole-3-amine with aldehydes in acetic acid. Then, sodium borohydride was selected as a reducing agent, which allowed for the restoration of the double bond. The structures of synthesized compounds were confirmed by IR, 1H NMR and mass spectra. The synthesized compounds were evaluated for antimicrobial and antifungal activity by "serial dilutions" method. Result and Discussion: During the synthetic studies the new series of 22 compounds were obtained. The 5- (1Н-tetrazole-1-yl-methyl)-4H-1,2,4-triazole-3-yl-1-(5-nitrofuran-2-yl)methanimine was observed to be most possessing good antimicrobial and antifungal activity and has exceeded the reference standard for Staphylococcus aureus (12,5/25 mg/ml), Escherichia coli (50/100 mg/ml), Pseudomonas Aeruginosa (100/200 mg/ml), Candida albicans (50/50 mg/ml).tr_TR
dc.identifier.endpage88tr_TR
dc.identifier.issn/e-issn1015-3918
dc.identifier.issue01tr_TR
dc.identifier.startpage70tr_TR
dc.identifier.urihttps://doi.org/10.33483/jfpau.574001tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/71150
dc.identifier.volume44tr_TR
dc.language.isoentr_TR
dc.publisherAnkara Üniversitesitr_TR
dc.relation.isversionof10.33483/jfpau.574001tr_TR
dc.relation.journalAnkara Üniversitesi Eczacılık Fakültesi Dergisitr_TR
dc.relation.publicationcategoryMakale - Ulusal - Editör Denetimli Dergi - Başka Kurum Yazarıtr_TR
dc.subject1,2,4-triazoletr_TR
dc.subjectAntimicrobial and antifungal activitytr_TR
dc.titleDesign, synthesis, antimicrobial and antifungal activities of new 1,2,4-triazole derivatives containing 1h-tetrazole moietytr_TR
dc.title.alternative1h-tetrazol içeren yeni 1,2,4-triazol türevlerinin tasarımı, sentezi, antimikrobiyal ve antifungal aktiviteleritr_TR
dc.typeArticletr_TR

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