Synthesis and antiradical activity of alkyl derivatives of 5-(5-methyl-1h-pyrazol-3-yl)-4-phenyl-4h1,2,4-triazole-3-thiol

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dc.contributor.authorGotsulya, Andrey
dc.contributor.authorIDhttps://orcid.org/0000-0001-9696-221Xtr_TR
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.date.accessioned2020-04-25T11:25:53Z
dc.date.available2020-04-25T11:25:53Z
dc.date.issued2020
dc.description.abstractObjective: The aim of the work was to develop effective methods for the synthesis of biologically active heterocyclic systems containing 1,2,4-triazole and pyrazole. Material and Method: Chemical structures of synthesized compounds were characterized with elemental analysis, IR, 1 H-NMR, LC-MS techniques. The antiradical activity was evaluated using the 2,2-diphenyl-1- picrylhydrazyl (DPPH) radical scavenging activity assay. Result and Discussion: Developed optimal methods of obtaining of alkylderivatives of 5-(5-methyl-1H-pyrazol3-yl)-4-phenyl-4H-1,2,4-triazole-3-thiol. A number of synthesized compounds showed moderate antiradical activity. Keywords: antiradical activity, pyrazole, synthesis,1,2,4-triazoles ÖZ Amaç: Çalışmanın amacı biyolojik olarak aktif 1,2,4-triazol ve pirazol içeren heterosiklik sistemlerin sentezi için etkili yöntemler geliştirmektir. Gereç ve Yöntem: Sentezlenen bileşiklerin kimyasal yapıları elemantal analiz, IR, 1 H-NMR, LC-MS teknikleri ile karakterize edildi. Antiradikal aktivite 2,2-difenil-1-pikrilhidrazil (DPPH) radikal süpürücü aktivite deneyi kullanılarak değerlendirildi. Sonuç ve Tartışma: 5-(5-metil-1H-pirazol-3-il)-4-fenil-4H-1,2,4-triazol-3-tiyol alkil türevlerinin elde edilmesi için optimum yöntemler geliştirildi. Bir dizi sentezlenmiş bileşik, orta derecede antiradikal aktivite göstermiştir.tr_TR
dc.identifier.endpage219tr_TR
dc.identifier.issn/e-issn1015-3918
dc.identifier.issue02tr_TR
dc.identifier.startpage211tr_TR
dc.identifier.urihttps://doi.org/10.33483/jfpau.616116tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/71154
dc.identifier.volume44tr_TR
dc.language.isoentr_TR
dc.publisherAnkara Üniversitesitr_TR
dc.relation.isversionof10.33483/jfpau.616116tr_TR
dc.relation.journalAnkara Üniversitesi Eczacılık Fakültesi Dergisitr_TR
dc.relation.publicationcategoryDKonferans Öğesi - Uluslararası - Başka Kurum Yazarıtr_TR
dc.subjectAntiradical activitytr_TR
dc.subjectPyrazoletr_TR
dc.subjectSynthesistr_TR
dc.titleSynthesis and antiradical activity of alkyl derivatives of 5-(5-methyl-1h-pyrazol-3-yl)-4-phenyl-4h1,2,4-triazole-3-thioltr_TR
dc.title.alternative5-(5-metil-1h-pirazol-3-il)-4-fenil-4h-1,2,4-triazol-3-tiyol alkil türevlerinin sentez ve antiradikal aktiviteleritr_TR
dc.typeArticletr_TR

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Cilt:44 Sayı:02 (2020)