Pegylated interferon-alpha plus taurine in treatment of rat liver fibrosis

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dc.contributor.authorBozdayı, Abdurrahman
dc.contributor.authorYurdaydın, Cihan
dc.contributor.authorBozkaya, Hakan
dc.contributor.authorVural, Sevil Atalay
dc.contributor.authorAlçığır, Günay
dc.contributor.departmentVeteriner Fakültesitr_TR
dc.date.accessioned2020-02-15T11:26:11Z
dc.date.available2020-02-15T11:26:11Z
dc.date.issued2007
dc.description.abstractAIM: To investigate the antifibrotic effects of peginterferon-alpha 2b and taurine on oxidative stress markers and hepatocellular apoptosis. METHODS: Sixty rats with CCl4-induced liver fibrosis were divided into 4 groups (n = 15). Group 1 was left for spontaneous recovery (SR). Groups 2-4 received peginterferon-alpha 2b, taurine, and their combination, respectively, for four weeks. Histological fibrosis scores, histomorphometric analysis, tissue hydroxyproline, tissue MDA, GPx and SOD activities were determined. Activated stellate cells and hepatocellular apoptosis were also evaluated. RESULTS: The degree of fibrosis decreased in all treatment groups compared to spontaneous recovery group. Taurine alone and in combination with peginterferon-alpha 2b reduced oxidative stress markers, but peginterferon-alpha 2b alone did not. Apoptotic hepatocytes and activated stellate cells were higher in groups 2-4 than in group 1. Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone. CONCLUSION: Peginterferon-alpha 2b exerts anti-fibrotic effects on rat liver fibrosis. It seems ineffective against oxidative stress in vivo. Peginterferon-alpha 2b in combination with taurine seems to be an antifibrotic strategy.tr_TR
dc.description.indexScopus
dc.description.indexWos
dc.identifier.endpage3244tr_TR
dc.identifier.issn/e-issn1007-9327
dc.identifier.issue23tr_TR
dc.identifier.startpage3237tr_TR
dc.identifier.urihttps://doi.org/10.3748/wjg.v13.i23.3237tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/69544
dc.identifier.volume13tr_TR
dc.language.isoentr_TR
dc.relation.isversionof10.3748/wjg.v13.i23.3237tr_TR
dc.relation.journalWorld Journal of Gastroenterologytr_TR
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıtr_TR
dc.rightsCC0 1.0 Universal*
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.subjectLiver fibrosistr_TR
dc.subjectLiver cirrhosistr_TR
dc.subjectPegylated interferonstr_TR
dc.titlePegylated interferon-alpha plus taurine in treatment of rat liver fibrosistr_TR
dc.typeArticletr_TR

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