Cilt:43 Sayı:02 (2019)

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Piperidinium 2-((5-(FURAN-2-YL)-4-PHENYL-4H-1,2,4-TRIAZOL)-3- YL) acetate forced degradation study
(Ankara : Ankara Üniversitesi, 2019) Varynskyi, Borys; Eczacılık Fakültesi
Objective: Aim of the research to make forced degradation study of piperidinium 2-((5-(furan-2-yl)-4- phenyl-4H-1,2,4-triazol)-3-yl) acetate in active pharmaceutical ingredient (API), 0.1% solution and 1% solution for injection. Influence of the sodium hydroxide, hydrochloride acid, 3% Н2О2, temperature, UV radiation on piperidinium 2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol)-3-yl) acetate substance, 0.1% solution and 1% solution for injections was studied. Material and Method: Agilent 1260 Infinity HPLC System. Agilent single-quadrupole mass spectrometer 6120. Result and Discussion: Dependence of the quantitative content of the piperidinium 2-((5-(furan-2-yl)-4- phenyl-4H-1,2,4-triazol)-3-yl) acetate from exposition time was determined. The composition of degradation products formed under the action of an oxidizer (3%Н2О2) was established. The composition of degradation products which were formed under the influence of UV radiation was proposed.