Piperidinium 2-((5-(FURAN-2-YL)-4-PHENYL-4H-1,2,4-TRIAZOL)-3- YL) acetate forced degradation study
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Date
2019
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Journal Title
Journal ISSN
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Publisher
Ankara : Ankara Üniversitesi
Abstract
Objective: Aim of the research to make forced degradation study of piperidinium 2-((5-(furan-2-yl)-4-
phenyl-4H-1,2,4-triazol)-3-yl) acetate in active pharmaceutical ingredient (API), 0.1% solution and 1%
solution for injection. Influence of the sodium hydroxide, hydrochloride acid, 3% Н2О2, temperature, UV
radiation on piperidinium 2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol)-3-yl) acetate substance, 0.1% solution
and 1% solution for injections was studied.
Material and Method: Agilent 1260 Infinity HPLC System. Agilent single-quadrupole mass spectrometer
6120.
Result and Discussion: Dependence of the quantitative content of the piperidinium 2-((5-(furan-2-yl)-4-
phenyl-4H-1,2,4-triazol)-3-yl) acetate from exposition time was determined. The composition of degradation
products formed under the action of an oxidizer (3%Н2О2) was established. The composition of degradation
products which were formed under the influence of UV radiation was proposed.
Description
Keywords
ESI mass spectrometry, Forced degradation study