Piperidinium 2-((5-(FURAN-2-YL)-4-PHENYL-4H-1,2,4-TRIAZOL)-3- YL) acetate forced degradation study

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dc.contributor.authorVarynskyi, Borys
dc.contributor.departmentEczacılık Fakültesitr_TR
dc.date.accessioned2020-04-01T08:54:51Z
dc.date.available2020-04-01T08:54:51Z
dc.date.issued2019
dc.description.abstractObjective: Aim of the research to make forced degradation study of piperidinium 2-((5-(furan-2-yl)-4- phenyl-4H-1,2,4-triazol)-3-yl) acetate in active pharmaceutical ingredient (API), 0.1% solution and 1% solution for injection. Influence of the sodium hydroxide, hydrochloride acid, 3% Н2О2, temperature, UV radiation on piperidinium 2-((5-(furan-2-yl)-4-phenyl-4H-1,2,4-triazol)-3-yl) acetate substance, 0.1% solution and 1% solution for injections was studied. Material and Method: Agilent 1260 Infinity HPLC System. Agilent single-quadrupole mass spectrometer 6120. Result and Discussion: Dependence of the quantitative content of the piperidinium 2-((5-(furan-2-yl)-4- phenyl-4H-1,2,4-triazol)-3-yl) acetate from exposition time was determined. The composition of degradation products formed under the action of an oxidizer (3%Н2О2) was established. The composition of degradation products which were formed under the influence of UV radiation was proposed.tr_TR
dc.identifier.endpage134tr_TR
dc.identifier.issn/e-issn1015-3918
dc.identifier.issue02tr_TR
dc.identifier.startpage117tr_TR
dc.identifier.urihttps://doi.org/10.33483/jfpau.480073tr_TR
dc.identifier.urihttp://hdl.handle.net/20.500.12575/70848
dc.identifier.volume43tr_TR
dc.language.isoentr_TR
dc.publisherAnkara : Ankara Üniversitesitr_TR
dc.relation.isversionof10.33483/jfpau.480073tr_TR
dc.relation.journalAnkara Üniversitesi Eczacılık Fakültesi Dergisitr_TR
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Başka Kurum Yazarıtr_TR
dc.subjectESI mass spectrometrytr_TR
dc.subjectForced degradation studytr_TR
dc.titlePiperidinium 2-((5-(FURAN-2-YL)-4-PHENYL-4H-1,2,4-TRIAZOL)-3- YL) acetate forced degradation studytr_TR
dc.title.alternativePiperidinyum 2-((5-(FURAN-2-İL)-4-FENİL-4H-1,2,4-TRİAZOL)-3-İL) asetatın zorlanmış bozunma çalışmasıtr_TR
dc.typeArticletr_TR

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